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In vivo studies show anatomically selective neurochemical outcomes of modafinil on monoaminergic systems (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, whilst modafinil raises TMN fos expression (Scammell et al 2000) and HAergic tone it is unable to exert this outcome when administered immediately in to the TMN (Ishizuka et al 200